The survival of factor VIII (antihemophilic globulin) and factor IX (plasma thromboplastin component) in normal humans.
نویسندگان
چکیده
منابع مشابه
An alternative extrinsic pathway of human blood coagulation.
To study the interrelationships of the major human coagulation pathways, factor X activation in normal and various deficient human plasmas was evaluated when clotting was triggered by dilute rabbit or human thromboplastin. Various dilutions of thromboplastin were added to plasma samples containing 3H-labeled factor X, and the time course of factor X activation was determined. At a 1/250 dilutio...
متن کاملComparison of factor deficient plasmas for measuring Factor VIII and IX
Introduction Factor dosages are part of the diagnostic work up in patients with bleeding tendency (factor (F) VIII and FIX) or in thrombophilia screening (FVIII). The correct diagnosis of FVIII and FIX deficiency and the assessment of severity of the disease are essential for a patient-tailored treatment strategy. Persistently high levels of FVIII are regarded as a thrombophilia risk marker. FV...
متن کاملImportance of factor-IX-dependent prothrombinase formation--the Josso pathway--in clotting plasma.
We report a study on the importance of factor IX activation in thromboplastin-dependent coagulation in plasma. Diluted, CaCl2-containing thromboplastin solutions at constant phospholipid concentration were used to trigger the coagulation in plasma from patients with congenital factor IX and factor VIII deficiency in the presence and absence of added factors IX and VIII, and the generation of th...
متن کاملThe importance of activation of antihemophilic globulin and proaccelerin by traces of thrombin in the generation of intrinsic prothrombinase activity.
seconds.2 Therefore, although the PTT measures the over-all time of the intrinsic clotting reactions, in most circumstances it essentially measures the rate of generation of intrinsic prothrombinase. It is now generally accepted that contact with a negatively charged surface such as glass initiates clotting in vitro by activating Hageman factor ( HF, factor XII ) . Activated HF then reacts with...
متن کاملPartial Thromboplastin Time Test with Kaolin. Normal Range and Modifications for the Diagnosis of Haemophilia and Christmas Disease.
The partial thromboplastin time test provides a convenient and sensitive screening procedure for deficiencies of thromboplastic factors, especially factors VIII and IX. The test is carried out after preincubating the plasma for 10 minutes with kaolin, and Inosithin is used as a platelet substitute. The ;normal range' of the test has been estimated in terms of the differences encountered between...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 42 شماره
صفحات -
تاریخ انتشار 1963